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KMID : 1134819980270020359
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 2 p.359 ~ p.365
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Antimutagenic Effect of Korean Mistletoe Extracts
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Ham Seung-Shi
Kang Shin-Tae
Chio Geun-Pyo
Park Won-Bong
Lee Deuk-Sik
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Abstract
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This study was carried out to investigate mutagenecity and antimutagenic effects from crude extract, heating extract and alcohol extract of Korean mistletoe (Viscum album L.) on the bacterial short-term tests, such as Ames test, spore rec-assay, SOS spot test and SOS chromotest by using several kinds of mutagens. In the Ames test, each extract did not show any mutagenesis, but each extract showed inhibitory effects of 80~95% and 70~94% against mutagenesis induced by 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole(Trp-P-l) and 2-aminofluorene(2-AF) in Salmonella typhimurium TA98, respectively. In the spore rec-assay, mistletoe extracts showed antimutagenic effects with inhibition zone in the range of 5~11㎜ against mutagenicity induced by mitomycin C(MMC, 18㎜) and N-methyl-N’-nitro-N-nitrosoguanidine(MNNG, 24㎜), respectively. The heating and alcohol extracts in the SOS chromotest showed 96% and 70% inhibition against benzo-α-pyrene[B(α)P] and Trp-P-l induced mutagenesis, respectively.
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KEYWORD
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Korean mistletoe, Ames test, spore rec-assay, SOS chromotest
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